Sildenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP) specific phosphodiesterases type 5 (PDE5). The physiologic mechanism of erection of the penis involves release of Nitric Oxide (NO) in the corpus cavernosum during sexual stimulation. NO then activates the enzymes gyanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood. Sildenafil has no direct relaxant effect on isolated human corpus cavernosum, but enhances the effect of Nitric Oxide (NO) by inhibiting phosphodiesterases type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum. When sexual stimulation causes local release of NO, inhibition of PDE5 by Sildenafil causes increase level of cGMP in the corpus cavernosum resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum. Sildenafil at recommended doses has no effect in the absence of sexual stimulation.

Price:
Price 10.0 USD ($) / UNIT
Minimum Order Quantity : 1000
Dosage : As prescribed by the physician
Ingredients : Sildenafil Citrate & Depoxetine HCl
Storage Instructions : Store in a cool, dry place away from sunlight
Drug Type : Other, Allopathic
Price 1.0 USD ($) / Box
Minimum Order Quantity : 500 Boxes
Dosage : 100, 250,325, 500,650 mg
Ingredients : Paracetamol 100, 250,325, 500,650 mg
Storage Instructions : Store in a cool and dry environment.
Drug Type : General Medicines
Price 13.5 USD ($) / Box
Minimum Order Quantity : 1000 Boxes
Dosage : As Directed By Physician
Ingredients : Ivermectin 3/6/12 mg
Storage Instructions : Store In a Cool & Dry Place
Drug Type : General Medicines
Price 0.8 USD ($) / Box
Minimum Order Quantity : 1000 Boxes
Dosage : As Directed By Physician
Ingredients : Sildenafil 100 mg
Storage Instructions : Store In a Cool & Dry Place
Drug Type : General Medicines