About Captopril API
Captopril(rINN)is anangiotensin-converting enzyme (ACE) inhibitorused for the treatment ofhypertensionand some types ofcongestive heart failure. Captopril was the first ACE inhibitor developed and was considered a breakthrough both because of its novel mechanism of action and also because of the revolutionary development process.
Specification:
| Product name |
Captopril |
| Appearance |
White or almost white crystalline powder |
| Solubility |
Freely soluble in water,in methylene chloride and in methanol.
It dissolves in dilute solutions of alkali hydroxides.
|
| Identification |
Ir spectrum conformod tothat of captopril crs |
| Appearance of solutions |
Clear and colorless |
| Melting range |
Between 104 and 110 |
| Specific optical rotation |
-125 to -130 |
| Related substance
Ampa
Captopril disulfide
Single unknown impurity
Tctal unknown impurities
|
Not more than 0.2%
Not more than 1.0%
Not more than 0.2%
Not more than 0.5%
|
| Heavy metals |
Not more than 0.003% |
| Loss on drying |
Not more than 1.0% |
| Sulphated ash |
Not more than 0.2% |
| Assay |
97.5%~102.0% calculated on anhydrous basis |
Packaging details:
| Packaging details: |
25kg/drum with double plastic bags inside; packed in a cardboard drum or fiber HDPE drum. |
| Storage: |
Stored in a clean, cool, dry area; keep away from moisture and strong, direct light/heat |
| Shelf Life: |
5 years if sealed and store away from direct sun light. |
Key Properties and ApplicationsCaptopril API distinguishes itself with excellent solubility and stable physical attributes. Due to its dependable antihypertensive action, it is extensively used in the formulation of medications aimed at controlling blood pressure. Pharmaceutical entities trust Captopril's purity and performance for consistent manufacturing outcomes.
Safe Storage and LongevityProper storage is essential to maintain the potency and quality of Captopril API. The compound should be kept away from moisture and stored in cool, dry conditions to ensure its five-year shelf life. Adhering to these storage guidelines helps prevent degradation and maintains the product's effectiveness.
Advantages in Pharmaceutical ManufacturingChoosing Captopril API offers several benefits, including straightforward integration into a range of formulations. Its reliable chemical stability and antimicrobial capabilities make it a preferred choice among manufacturers, suppliers, and distributors, contributing to high-quality pharmaceutical products.
FAQ's of Captopril API:
Q: How should Captopril API be stored to maintain its efficacy?
A: Captopril API should be stored in a cool, dry place and kept away from moisture. This ensures its stability, retains its white to off-white crystalline appearance, and preserves its potency throughout its five-year shelf life.
Q: What is the typical usage of Captopril API in pharmaceuticals?
A: Captopril API is primarily used as an antihypertensive agent in the manufacturing of medications that treat high blood pressure. Its antimicrobial and antibiotic properties also enhance its value in pharmaceutical applications.
Q: When does Captopril API reach its maximum shelf life, and how long does it last?
A: Captopril API, when properly stored as per recommended guidelines, reaches its maximum shelf life of five years. Avoiding exposure to moisture is crucial for maintaining this longevity.
Q: Where is Captopril API supplied and distributed from?
A: Captopril API is widely available through various channels, including distributors, exporters, manufacturers, suppliers, traders, and wholesalers, ensuring accessible supply for pharmaceutical producers.
Q: What is the process for incorporating Captopril API into drug formulations?
A: Pharmaceutical manufacturers typically mix Captopril API, which is a freely soluble powder, with other excipients as part of their drug formulation process. Its chemical compatibility and solubility facilitate easy blending and incorporation.
Q: What benefits does Captopril API offer to pharmaceutical companies?
A: The main benefits of Captopril API include its reliable antihypertensive effect, five-year shelf life, ease of formulation due to its solubility, and consistent performance as an active pharmaceutical ingredient.